Open-label: the clinical effects of adding cannbidiol to usual care of patients with residual symptoms in the diagnosis of Obsessive Compulsive Disorder

نویسندگان

چکیده

Introduction Obsessive-compulsive disorder (OCD) is a heterogeneous and debilitating neuropsychiatric disorder. First-line antidepressants with Selective Serotonin Reuptake Inhibitors (SSRIs) Clomipramine (a tricyclic antidepressant) are unresponsive or partially responsive in 40% of treated patients. Preclinical studies have shown that cannabidiol (CBD) can reduce compulsive behavior animals, considering the release glutamate action CBD inhibit terminal axons neurons corticostriatal-thalamo-cortical circuit, we chosefor testing CBD, drug few side effects low toxicity, as an adjuvant treating OCD. Objectives To evaluate clinical add-on to usual pharmacological treatment outpatients diagnosed Methods Methods: This open-label study which patients received 300mg-day for 30 days addition their treatments 600mg-day additional if they not reduced at least 25% symptoms compared baseline evaluated by Yale-brown obsessive-compulsive scale (Y-BOCS). Psychometric scales were used assess CBD: Y-BOCS, General Anxiety Disorder 7 (GAD-7), Clinical Overall Impressions-Severity (CGI-S), Global Impressions-Improvement (CGI-I), Patient Health Questionnaire-9 (PHQ-9), Epworth Sleepiness Scale Udvalg Kliniske Undersogelser (UKU) scale. Participants: We initially assessed 33 participants study. So far, 19 completed Eleven did complete study, 03 still trial. Results Mean (SD) Y-BOCS scores decreased from 28.0 (4.8) 13.8 (8.6) week 8, corresponding - 50.7% reduction (P<.0001). (GAD-7 scale) (P=0.001) CGI-Severity (P<0.001) improved significantly. Measure Baseline, Week 4, Change (Baseline 4) 8) p-value t-test Y-Bocks 17.8 (7.3) 10.1 (6.5) <0,001 7.1 14.1 (7.9) 7.7 GAD-7 (4.4) 8.14 (4.9) 8.0 (5.7) 5.7 (6.4) 0,001 4.0 5.6 (5.8) 4.1 CGI-I 5.48 (0.9) 3.9 (1.3) 3.3 (1.5) 1.5 5.28 2.1 (1.2) 7.4 n=22; b n=19 Image: Image 2: 3: Conclusions concluded there was important psychometric statistical significance. partial analysis results progresses. believe future will be able this better promising. At end other such CGI-I, epworth UKU analyzed. Disclosure Interest None Declared

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ژورنال

عنوان ژورنال: European Psychiatry

سال: 2023

ISSN: ['0924-9338', '1778-3585']

DOI: https://doi.org/10.1192/j.eurpsy.2023.524